A NEW ERA OF HEALTHY AGING

 

ENABLING THE POTENTIAL OF NATURE

 

EXPERIENCE WHAT'S POSSIBLE

START WITH HALO

Enabling Possible.

Healthy metabolic function is fundamental to healthy aging, resilience, and overall wellness. As interest in precision health, healthy aging, and extending Healthspan continues to grow, there is increasing demand for innovative technologies that unlock the full potential of compounds used across nutrition, performance, and medicine.

Yet nearly 90% of compounds exhibit poor water solubility, limiting formulation flexibility, utilization, manufacturability, and overall performance. Halo was founded to solve this fundamental challenge. Powered by our patented IONx™ platform, we engineer the performance of compounds through advanced chemistry, artificial intelligence, and precision biomanufacturing creating new opportunities for our partners and enabling the next generation of precision nutrition, precision health, and sustainable innovation.

At Halo, we believe that when compounds achieve their full potential, so can the products, industries, and people they ultimately serve.

Enabling Bioactives, Enabling Health.

At Halo, we’re redefining how nature’s most promising bioactive compounds are formulated, delivered, and utilized. Powered by our patented IONx™ process platform, Naturalin® is a highly soluble, naturally derived ellagic acid bioactive and only precursor to the family of fermented natural urolithins (A–G), Naturalithins™. Combined with our patent-pending bacterial consortia, these innovations enable scalable production of naturally derived urolithins, in vivo and ex vivo, opening the door to the next generation of healthy aging, precision nutrition, and precision health solutions. Naturalin® represents the first demonstration of what the IONx platform can achieve.

 

A Platform, Not a Product

Naturalin® is only the beginning. Our AI-powered IONx™ adaptive performance engine is transforming how bioactive compounds are optimized for real-world applications. Already demonstrating significant solubility improvements across multiple classes compounds, the platform continues to expand its optimized compounds library creating new opportunities for food, nutrition, pharmaceutical, and consumer health partners to unlock the full potential of their own bioactive compounds.

Naturalin® Mechanisms & Function Highlights

The following represents key learnings related to the mechanisms of Naturalin’s core compounds Ellagic Acid and Choline.

Signaling

Naturalin signals multiple cell types, promotes GLUT4 translocation, and significantly enhances glucose uptake compared with established research standards.

Naturalin® Cell Signaling Video

Inhibition

Ellagic Acid is among the most potent known CK2 inhibitors. Preclinical studies suggest Naturalin supports key cellular pathways involved in glucose metabolism, lipid metabolism, and cellular signaling.

Antagonism

In preclinical research, Naturalin showed antagonism of SARS-CoV-2 Spike protein and Angiotensin-Converting Enzyme 2 (ACE2) interactions, reduced binding and exocytosis.

Activation

Preclinical studies suggest Naturalin supports key cellular pathways involved in glucose metabolism, lipid metabolism, and cellular signaling.

HALO AREAS OF FOCUS

MET-01

Metabolic Health

IMU-02

Immunity

LVR-03

Liver Health

SKN-04

Skin Health

BRN-05

Brain Health

THE MICROBIOME & “POSTBIOTICS”

Halo’s high soluble, Naturalin®, enables the increase in production of metabolite urolithins (“postbiotics”) by over 1,000x more than ever before.

Urolithins have been shown to enhance cellular and mitochondrial function, support muscle health, and support metabolic health.

CHALLENGING CORONAVIRUS WITH POLYPHENOLS

In preclinical studies, Naturalin demonstrated antagonism of SARS-CoV-2 Spike-protein.

[  VIDEO  ]

HISTORY REMINDS US

Historically, and especially in the case of pandemics, solutions were delivered through staple foods.

Iodine in salt for goiter, vitamin C to tackle scurvy, folate to help reduce the risk of birth defects, fluoride in water for oral health. Today, we are facing two such global health crisis – obesity and a novel virus. Halo products provide support to fight against both and their underlying causes.

At Halo, we are guided by purpose and science. We believe that “good science” takes time and purpose takes commitment.

At Halo, we approach our work with the belief that our health is the most valuable asset each of us posses.

“Constantly challenge one another and dogma, be unorthodox, collaborate and serve humankind”

DEMOCRATIZING HEALTH

There are many factors that directly impact our health, or lack of it, such as knowledge, education, sedentary lifestyles, and cultural and socio-economic challenges. Most better-for-you (BFY) foods and health-improving supplements are globally unavailable and unaffordable for most.

At Halo, we believe everyone should have affordable, accessible, nutritious food and supplements. And we believe it’s possible.

FORTIFYING HUMANKIND™

Halo is committed to making everything we eat and drink better-for-you through fortification and enrichment. Foods fortified with vital nutrients and Naturalin® help to support overall wellness.

HALO FOODS

Halo Foods are imagined as a better choice to the highly-processed, high-carb, high sugar, nutrient starved food choices that have lead to a very unhealthy world.  The public’s loss of confidence and faith in nutritional guidance leaves them hungry for alternatives they can trust, afford and that will positively impact their lives. It is our vision and mission to meet this need.

TEAM & ADVISORY

MICHAEL REYES
FOUNDER, CEO
ROBERT M. CABRERA, PhD
CHIEF SCIENCE OFFICER
DIPIKA MATTHIAS
BOARD ADVISOR
SIOBHAN DULLEA
BOARD ADVISOR
JASON JONES
BOARD ADVISOR
CHRISTOPHER S. SMITH
BOARD ADVISOR
SILVIA BARBARESI, PhD
SCIENCE ADVISOR
JEFFREY SKOLNICK
AI-SCIENCE ADVISOR
ALEJANDRA CARRASCO MD
SCIENCE ADVISOR
PATRICK HANAWAY, MD
SCIENCE ADVISOR
RANDOLPH SMOAK JR. MD
SCIENCE ADVISOR

BLOG & NEWS

Lifecode
December 20, 2020

BIOLOGICAL BACKUPS

For four billion years, what lived and died on Earth…
michaelreyesusa
Love6
Obesity
December 19, 2020

FOOD CULTURE

I profoundly believe that the power of food has a primal…
michaelreyesusa
Love8
MICROBIOME
December 19, 2020

GUT BRAIN

The notion that the state of our gut governs our…
michaelreyesusa
Love7
FOOD
February 5, 2017

FORTIFYING HUMANKIND

Halo was born out of a personal need to find…
michaelreyesusa
Love5

GET IN TOUCH

Halo encourages anyone interested in collaborating, sharing ideas or simply to
connect to reach out to us. You can never have enough good ideas or friends.

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Victoria, Texas USA